University of Cape Town
2 files

Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection

posted on 2021-06-21, 13:05 authored by Cheleka MpandeCheleka Mpande, Munyaradzi MusvosviMunyaradzi Musvosvi, Virginie RozotVirginie Rozot, Boitumelo Mosito, Timothy Reid, Constance Schreuder, Tessa LloydTessa Lloyd, Nicole Bilek, Huang Huang, Gerlinde Obermoser, Mark M Davis, Morten Ruhwald, Mark Hatherill, Thomas ScribaThomas Scriba, Elisa NemesElisa Nemes
This dataset (Mycobacterium tuberculosis-specific T cells in recent and remote M.tb infection, and TB disease) contains M.tb-specific CD4 T cell function (IFN-g, TNF, IL-2), memory (CD45RA, CCR7) and activation (HLA-DR) profiles detected by flow cytometry or transcriptomics after CFP-10/ESAT-6 or M.tb lysate stimulation of PBMC from recent and persistent QFT+ individuals, and TB patients at diagnosis included in the manuscript "Antigen-specific T cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection". See paper for more details. Data sets included for each figure are indicated in the sheet name; Column names indicate: SubjectID, Group, Stimulation (stim) and the respective variable measured.


Immunological significance of QuantiFERON TB Gold In-tube reversions in settings with high burden of tuberculosis

National Institute of Allergy and Infectious Diseases

Find out more...

To identify prospective immune correlates of risk of tuberculosis (TB) disease following natural infection with Mycobacterium tuberculosis

Bill & Melinda Gates Foundation

Find out more...

To establish a state-of-the-art center for immunological analysis at Stanford University, with the goal of accelerating global health and vaccine research by bring to bear upon these problems the talents of some of the world leaders in immu

Bill & Melinda Gates Foundation

Find out more...

Bill & Melinda Gates Grand Challenges 6-74 Grant 37772

Bill & Melinda Gates Grand Challenges 12 Grant 37885


Strategic Health Innovation Partnerships (SHIP) Unit of the South African Medical Research Council with funds received from the South African Department of Science and Technology

Carnegie Corporation of New York

South African National Research Foundation

University of Cape Town



South African Tuberculosis Vaccine Initiative (SATVI)