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Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection
dataset
posted on 2021-06-21, 13:05 authored by Cheleka MpandeCheleka Mpande, Munyaradzi MusvosviMunyaradzi Musvosvi, Virginie RozotVirginie Rozot, Boitumelo Mosito, Timothy Reid, Constance Schreuder, Tessa LloydTessa Lloyd, Nicole Bilek, Huang Huang, Gerlinde Obermoser, Mark M Davis, Morten Ruhwald, Mark Hatherill, Thomas ScribaThomas Scriba, Elisa NemesElisa NemesThis dataset (Mycobacterium tuberculosis-specific T cells in recent and remote M.tb infection, and TB disease) contains M.tb-specific CD4 T cell function (IFN-g, TNF, IL-2), memory (CD45RA, CCR7) and activation (HLA-DR) profiles detected by flow cytometry or transcriptomics after CFP-10/ESAT-6 or M.tb lysate stimulation of PBMC from recent and persistent QFT+ individuals, and TB patients at diagnosis included in the manuscript "Antigen-specific T cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection". See paper for more details. Data sets included for each figure are indicated in the sheet name; Column names indicate: SubjectID, Group, Stimulation (stim) and the respective variable measured.
Funding
Immunological significance of QuantiFERON TB Gold In-tube reversions in settings with high burden of tuberculosis
National Institute of Allergy and Infectious Diseases
Find out more...To identify prospective immune correlates of risk of tuberculosis (TB) disease following natural infection with Mycobacterium tuberculosis
Bill & Melinda Gates Foundation
Find out more...To establish a state-of-the-art center for immunological analysis at Stanford University, with the goal of accelerating global health and vaccine research by engaging the talents of some of the world leaders in immunology.
Bill & Melinda Gates Foundation
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