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Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection

dataset
posted on 21.06.2021, 13:05 by Cheleka MpandeCheleka Mpande, Munyaradzi MusvosviMunyaradzi Musvosvi, Virginie RozotVirginie Rozot, Boitumelo Mosito, Timothy Reid, Constance Schreuder, Tessa LloydTessa Lloyd, Nicole Bilek, Huang Huang, Gerlinde Obermoser, Mark M Davis, Morten Ruhwald, Mark Hatherill, Thomas ScribaThomas Scriba, Elisa NemesElisa Nemes
This dataset (Mycobacterium tuberculosis-specific T cells in recent and remote M.tb infection, and TB disease) contains M.tb-specific CD4 T cell function (IFN-g, TNF, IL-2), memory (CD45RA, CCR7) and activation (HLA-DR) profiles detected by flow cytometry or transcriptomics after CFP-10/ESAT-6 or M.tb lysate stimulation of PBMC from recent and persistent QFT+ individuals, and TB patients at diagnosis included in the manuscript "Antigen-specific T cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection". See paper for more details. Data sets included for each figure are indicated in the sheet name; Column names indicate: SubjectID, Group, Stimulation (stim) and the respective variable measured.

Funding

Immunological significance of QuantiFERON TB Gold In-tube reversions in settings with high burden of tuberculosis

National Institute of Allergy and Infectious Diseases

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To identify prospective immune correlates of risk of tuberculosis (TB) disease following natural infection with Mycobacterium tuberculosis

Bill & Melinda Gates Foundation

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To establish a state-of-the-art center for immunological analysis at Stanford University, with the goal of accelerating global health and vaccine research by engaging the talents of some of the world leaders in immunology.

Bill & Melinda Gates Foundation

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Bill & Melinda Gates Grand Challenges 6-74 Grant 37772

Bill & Melinda Gates Grand Challenges 12 Grant 37885

Aeres

Strategic Health Innovation Partnerships (SHIP) Unit of the South African Medical Research Council with funds received from the South African Department of Science and Technology

Carnegie Corporation of New York

South African National Research Foundation

University of Cape Town

History

Department/Unit

South African Tuberculosis Vaccine Initiative (SATVI)