In silico mechanics and TGF-ß expression of stem cells intramyocardially transplanted with a biomaterial injectate for treatment of myocardial infarction.

Excel files: 3x

1) cell stretching studies.xlsx: data from the cell stretching model. Average strain in substrate, focal adhesions, and the cell body.

2) cellStrainData.xlsx: End-systolic and end-diastolic maximum and minimum principal strain for cell components (membrane, cytoplasm and nucleus), ED-ES maximum and minimum principal strain ranges

3) ED_ES_Strain_Injectate.xlsx: End-systolic and end-diastolic maximum and minimum principal strain in injectate

  

Finite element models: 3x

1) BV_Model.cae: Abaqus CAE file of the biventricular FE model with material parameters for the injectate and the myocardium implemented

2) CellStretch.cae: Abaqus CAE file of cell stretch model comprising single cell and the substrate with material parameters for the cellular components(membrane, cytoplasm, nucleus) and the substrate implemented 

3) subModel.cae: Abaqus CAE file of the microstructural submodel with material parameters for the cellular components (membrane, cytoplasm, nucleus) implemented

Python files: 3x

1) cell_seeding.py: Numercical seedign of cells in submodel

2) boxplotED_ES_MaxPrinc.py: loads strain data and plot box plot figures of injectate

3) postProcesDataPlotFunctions.py: contains function to plot histograms and box plots