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Predictive and diagnostic performance of Tuberculosis transcriptomic biomarker in BCG associated IRIS

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posted on 08.04.2022, 06:31 by Stanley KimbungStanley Kimbung, Hannah Painter, Adam Penn-Nicholson, Asma Toefy, Mzwandile Erasmus, Willem A. Hanekom, Thomas ScribaThomas Scriba, Rachel P.J Lai, Suzaan Marais, Helen A. Fletcher, Graeme Meintjes, Robert J. Wilkinson, Mark F. Cotton, Savita Pahwa, Mark J. Cameron, Elisa NemesElisa Nemes
RISK6 and DIAG3 signatures scores for a subset of ART-naïve HIV+ infants and young children who were enrolled into the observational multi-centered prospective clinical study in the International Maternal, Pediatric, Adolescent AIDS Clinical Trial (IMPAACT) network. Signature scores were computed from gene expression measurements performed by microfluidic RT-qPCR on mRNA derived from whole blood collected in PAXgene tubes. Also include are signature scores computed from publish microarray datasets: GSE83892 and GSE58411

Funding

IMPAACT Leadership Group

National Institute of Allergy and Infectious Diseases

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SDMC - IMPAACT Leadership Group

National Institute of Allergy and Infectious Diseases

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International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network

National Institute of Allergy and Infectious Diseases

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Miami Center for AIDS Research pilot grant (663179)

Kennedy Shriver National Institute of Child Health and Human Development (HHSN275201800001I)

UK Medical Research Council (studentship MR/N013638/1)

History

Department/Unit

Department of Pathology