Supplementary Material - Group A streptococcus (GAS) virulence factors associated with invasive disease: A Systematic Review

Supplementary materials to the following publication submitted for review:

Rampersadh, et al. Group A streptococcus (GAS) virulence factors associated with invasive disease: A Systematic Review.

The data contains the following tables: 

Table S1. Search strategy for PubMed database 

Table S2. Characteristics of excluded studies.

Table S3. Risk of bias of the included studies.

Table S4. Study data of all virulence factors in all the studies (classification-cell surface, secretory, both or other).

Table S5. Meta - analyses of the association of secretory virulence factors and invasive  infection (lab method: PCR; Low ROB)

Table S6. Distribution of emm cluster in invasive GAS infections. 

Table S7.  Extract of the more significant emm clusters associated with the significant  virulence factors.

Table S8. Significant associations between virulence genes and invasive infection.