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Hierarchy of molecular phenotypes in developing mouse embryos

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posted on 2011-12-30, 18:17 authored by Amar V Singh, Kenneth B Knudsen, Thomas B Knudsen

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Taken from "Integrative analysis of the mouse embryonic transcriptome"

Bioinformation 2007;1(10):406-413.

Published online 10 Apr 2007

PMCID:PMC1896055.

In five GEO platforms (160 samples), 346 genes were found differentially expressed in BDSM profiles: preimplantation mouse embryo (GSE1749) [], heart (GSE1479) GD10 - GD18 [] nerve (GSE972) GD9.5 – birth []; ovary (GSE1359) and testis (GSE1358) GD11.5 – birth []; orofacial (GSE1624) [] and palate [] between GD13-15. Each developing organ system was properly ordered by its natural chronology, based on the 346 gene-expression signature and an unsupervised clustering algorithm with Pearson correlation. Gene colors are mapped by K-means clustering (6 sets).

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