Imputation and use in GWAS - Lecture 6 H3ABioNet 2018 GWAS Lecture series
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Imputation and its importance in GWAS
The sixth of a series of seven H3ABioNet online lectures for Genome Wide Association Studies (GWAS) will introduce the fundamentals of genotype imputation and its importance in GWAS. This lecture will cover the reference panels, file formats, algorithms and tools commonly used for imputation. It will discuss the assessment of the quality of imputation as well as the evaluation of reference panel and imputation methods. The lecture will also explain how imputation enhances the scope a GWAS and describe some of the additional analyses that become possible due to the use of imputed data.