Quality_control_and_its_importance_in_GWAS_Lecture_4.pdf (9.91 MB)
Quality control and its importance in GWAS - Lecture 4 H3ABioNet 2018 GWAS Lecture series
presentation
posted on 2018-09-11, 08:55 authored by Shaun AronQuality control and its importance in GWAS
In the fourth of a series of seven H3ABioNet online lectures for Genome Wide Association Studies (GWAS), the importance of doing good quality control for a GWAS will be discussed. The lecture will cover the types of errors one should control for, the specific bioinformatics tools used for quality control. Specific sample and SNP quality control steps that should be undertaken in a GWAS will be explored using specific examples.
Funding
Research reported in this publication was supported by the National Human Genome Research Institute of the National Institutes of Health under Award Number U24HG006941. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Genome Wide Association StudiesGenotype callingH3Africa genotyping arrayAfrican populationsQC for GWASGenome wide association study (GWAS)Sample Quality ControlSNP Quality ControlPopulation genomicsGenotypingPLINK formatPrincipal Component AnalysisLow minor allele frequencyMissingnessGWAS workflowDiscordant Sex informationNextflowGenotyping rate callHeterozygosity rateRelated and duplicate individualsIdentity by DescentHardy Weinberg EquilibriumBioinformaticsH3ABioNet GWAS 2018 Lecture SeriesH3ABioNetBioinformaticsBiological TechniquesComputational BiologyGeneticsGenomicsPopulation, Ecological and Evolutionary GeneticsQuantitative Genetics (incl. Disease and Trait Mapping Genetics)
