Supplementary Material - Group A streptococcus (GAS) virulence factors associated with invasive disease: a systematic review

Supplementary materials to the following publication submitted for review:

Rampersadh, et al. Group A streptococcus (GAS) virulence factors associated with invasive disease: A Systematic Review.

The data contains the following:

Fig S1. The most prevalent emm types identified amongst GAS studies.

Table S1. Search strategy for PubMed database.

Table S2. Characteristics of excluded studies.

Table S3. Risk of bias of the included studies.

Table S4. List of emm types significantly associated with invasive GAS infection.

Table S5. Study data of all virulence factors in all the studies (classification-cell surface, secretory, both or other).

Table S6. Meta-analyses of the association of secretory virulence factors and invasive infection (lab method: PCR; Low ROB).

Table S7. Distribution of emm cluster in invasive GAS infections.

Table S8. Extract of the more significant emm clusters associated with the significant virulence factors.

Table S9. Summary of emm clusters (>2 studies) associated with the significant virulence factors.