University of Cape Town
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Mark Engel

Professor (Health sciences)

Cape Town

Prof Mark Engel is a research scientist, networking with African colleagues to apply a wide range of investigative approaches, from molecular to population-based research to all aspects of rheumatic heart disease (RHD), a neglected disease affecting predominantly poorer people in Africa. In 2016, Mark established the AFROStrep Study, in efforts to improve the understanding of the role of group A streptococcus in RHD development. His work, supported over the years by the SA National Research Foundation, the SA Medical Research Council, the American Heart Association and NIH in the USA, has been presented both nationally and internationally.

Publications

  • Is the introduction of violence and injury observatories associated with a reduction in violence-related injury in adult populations? A systematic review and meta-analysis
  • Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: A systematic review and meta-analysis
  • Seven key actions to eradicate rheumatic heart disease in Africa: the Addis Ababa communique
  • Data Resource Profile: Cardiovascular H3Africa Innovation Resource (CHAIR)
  • Regional Patterns and Association Between Obesity and Hypertension in Africa Evidence From the H3Africa CHAIR Study
  • Reducing the Burden of Rheumatic Heart Disease: Prevalence of Group a Streptococcus emm Clusters in Africa Suggests Adequate Coverage by 30-Valent Vaccine
  • Prevalence of group A Streptococcal infection in Africa to inform GAS vaccines for rheumatic heart disease: A systematic review and meta -analysis
  • Correction: Rationale and design of the African group A streptococcal infection registry: The AFROStrep study (BMJ Open (2016) 6, (e010248))
  • Integrating the prevention and control of rheumatic heart disease into country health systems: A systematic review protocol
  • The effectiveness of peer and community health worker-led self-management support programs for improving diabetes health-related outcomes in adults in low- and-middle-income countries: A systematic review
  • Erratum for Barth et al., "Molecular Epidemiology of Noninvasive and Invasive Group A Streptococcal Infections in Cape Town"
  • Parents of children with disabilities: A systematic review of parenting interventions and self-efficacy
  • Rationale and design of the African group A streptococcal infection registry: the AFROStrep study
  • Factors associated with long-term mortality after Fontan procedures: a systematic review
  • Invasive and non-invasive group A β-haemolytic streptococcal infections in patients attending public sector facilities in South Africa: 2003–2015
  • Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease
  • The Health Systems Barriers and Facilitators for RHD Prevalence: An Epidemiological Meta-Analysis From Uganda and Tanzania
  • The Cape Town Clinical Decision Rule for Streptococcal Pharyngitis in Children
  • Predicting long-term mortality after Fontan procedures: A risk score based on 6707 patients from 28 studies
  • Prevalence and risk factors of latent tuberculosis infection in Africa: a systematic review and meta-analysis protocol
  • Asymptomatic rheumatic heart disease in South African schoolchildren: Implications for addressing chronic health conditions through a school health service
  • Participation in research improves overall patient management: insights from the Global Rheumatic Heart Disease registry (REMEDY)
  • Evaluation of a focussed protocol for hand-held echocardiography and computer-assisted auscultation in detecting latent rheumatic heart disease in scholars
  • Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis
  • Clinical Outcomes in 3343 Children and Adults with Rheumatic Heart Disease from 14 Low-and Middle-Income Countries: Two-Year Follow-Up of the Global Rheumatic Heart Disease Registry (the REMEDY Study)
  • Seven key actions to eradicate rheumatic heart disease in Africa: The Addis Ababa communiqu
  • Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations
  • Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever
  • Task sharing to improve the prevention, diagnosis and management of rheumatic heart disease: A systematic review protocol
  • Rationale and design of the violence, injury and trauma observatory (VITO): The Cape Town VITO pilot studies protocol
  • Prevalence of rheumatic heart disease in Zambian school children
  • Standard echocardiography versus handheld echocardiography for the detection of subclinical rheumatic heart disease: Protocol for a systematic review
  • Effectiveness of control measures to prevent occupational tuberculosis infection in health care workers: A systematic review
  • Task Sharing in the Diagnosis, Prevention, and Management of Rheumatic Heart Disease: A Systematic Review
  • Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa: A systematic review protocol
  • Prevalence of rheumatic heart disease among school children in Ethiopia: A multisite echocardiography-based screening
  • Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: A systematic review and meta-analysis
  • A Comprehensive Needs Assessment Tool for Planning RHD Control Programs in Limited Resource Settings
  • Is computer-assisted instruction more effective than other educational methods in achieving ECG competence among medical students and residents? Protocol for a systematic review and meta-analysis
  • Digoxin and clinical outcomes in the Global Rheumatic Heart Disease Registry
  • Genetic variants in rheumatic fever and rheumatic heart disease
  • Systematic review and meta-analysis of the prevalence of Strep A emm clusters in Africa to inform vaccine development
  • Does genetics matter for disease-related stigma? The impact of genetic attribution on stigma associated with rheumatic heart disease in the Western Cape, South Africa
  • Systematic Review and Meta-analysis of the Prevalence of Group A Streptococcal emm Clusters in Africa To Inform Vaccine Development
  • Molecular Epidemiology of Noninvasive and Invasive Group A Streptococcal Infections in Cape Town
  • Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis
  • Rapid review of Global Strep A emm types
  • Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals
  • An appraisal of laboratory models of androgenetic alopecia: A systematic review
  • Outcomes and complications of peripartum cardiomyopathy: protocol for a systematic review and meta-analysis
  • Rheumatic Fever: Neglected Again
  • Primary Prevention of Acute Rheumatic Fever and Rheumatic Heart Disease with Penicillin in South African Children with Pharyngitis: A Cost-Effectiveness Analysis
  • The Rheumatic Heart Disease Global Registry (REMEDY) study: preliminary report
  • Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review
  • Primary prevention of rheumatic fever in children: Key factors to consider Respone
  • Irlam et al. respond.
  • Erratum: (BMJ Open (2015) 5)
  • Incidence, prevalence and outcome of rheumatic heart disease in South Africa: A systematic review of contemporary studies
  • Tuberculosis surveillance in Cape Town, South Africa: an evaluation
  • Abnormal glucose metabolism in non-diabetic patients presenting with an acute stroke: prospective study and systematic review
  • Effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town: no evidence for an association
  • Prevalence of group A streptococcal disease in North and Sub-Saharan Africa: a systematic review protocol
  • Group A streptococcal emm type prevalence among symptomatic children in Cape Town and potential vaccine coverage
  • Clinical and epidemiological aspects of streptococcus pyogenes pharyngitis and carriage in Africa.
  • Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials
  • A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis
  • Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review
  • The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis
  • Is the introduction of violence and injury observatories associated with a reduction of violence in adult populations? Rationale and protocol for a systematic review
  • Genetic susceptibility to acute rheumatic Fever: a systematic review and meta-analysis of twin studies
  • Rheumatic heart disease in Africa: the Mosi-o-Tunya call to action
  • Rationale and design of a Global Rheumatic Heart Disease Registry: the REMEDY study
  • Mobile phone text messaging for improving the uptake of vaccinations: a systematic review protocol
  • An open-access, mobile compatible, electronic patient register for rheumatic heart disease ('eRegister') based on the World Heart Federation's framework for patient registers
  • The prevalence of type 2 diabetes among older people in Africa: a systematic review
  • N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review protocol
  • Rheumatic fever and rheumatic heart disease: Where are we now in South Africa?
  • Research capacity. Enabling the genomic revolution in Africa
  • Primary prevention of acute rheumatic fever and rheumatic heart disease with penicillin in South African children with pharyngitis: a cost-effectiveness analysis
  • Prevalence of rheumatic heart disease in 4720 asymptomatic scholars from South Africa and Ethiopia
  • The prevalence of type 2 diabetes mellitus among older people in Africa: a systematic review study protocol
  • Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review.
  • Rheumatic fever: Neglected again
  • Re: Primary prevention of rheumatic fever in children: Key factors to consider
  • Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study
  • Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: The Global Rheumatic Heart Disease Registry (the REMEDY study)
  • Letter to the editor
  • The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: A systematic review protocol
  • Effectiveness of community-based peer-led diabetes self-management programmes (COMP-DSMP) for improving clinical outcomes and quality of life of adults with diabetes in primary care settings in low and middle-income countries (LMIC): A systematic review and meta-analysis
  • The natural history of latent rheumatic heart disease in a 5 year follow-up study: A prospective observational study
  • The burden of antenatal heart disease in South Africa: A systematic review
  • Mycobacterium w immunotherapy for treating pulmonary tuberculosis - A systematic review
  • A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development
  • The importance of awareness and education in prevention and control of RHD
  • The second rheumatic heart disease forum report
  • Health education interventions to raise awareness of rheumatic fever: a systematic review protocol.
  • Incidence, prevalence and outcomes of rheumatic heart disease in South Africa: A systematic review protocol
  • Rheumatic Fever: Neglected Again
  • The Rheumatic Heart Disease Global Registry (REMEDY) study: preliminary report
  • Primary prevention of rheumatic fever in children: Key factors to consider Respone
  • Mobile phone text messaging for improving the uptake of vaccinations: a systematic review protocol
  • Mycobacterium w immunotherapy for treating pulmonary tuberculosis - a systematic review
  • Investigation for a 30bp deletion in the EBV LMP oncogene in South African Hodgkin's disease
  • No evidence for an association between the mitochondrial variant T16189C and dilated cardiomyopathy: A systematic review and meta-analysis
  • Acute rheumatic fever surveillance in South Africa: An evaluation tool based on the CDC guidelines for evaluating public health surveillance systems
  • Genetic contribution to rheumatic fever: A systematic review and meta-analysis of twin studies
  • Prevalence of Group A -hemolytic Streptococcal Throat Carriage and Prospective Pilot Surveillance of Streptococcal Sore Throat in Ugandan School Children
  • Regional patterns and the association between obesity and hypertension in Africa: 30,044 participants from the H3Africa CHAIR study across 13 countries.
  • Is computer-assisted instruction more effective than other educational methods in achieving ECG competence amongst medical students and residents? A systematic review and meta-analysis
  • RHD Forum Meeting Report Writing Committee. The Second Rheumatic Heart Disease Forum Report.
  • Corticosteroids for tuberculous pleurisy
  • Conducting a meta-ethnography of qualitative literature: lessons learnt
  • Patient adherence to tuberculosis treatment: a systematic review of qualitative research
  • The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
  • Rheumatic Heart Disease: The time has come.
  • Detection of EBV in 48 cases of South African childhood Hodgkin's disease
  • Paediatric rhabdomyosarcoma: MyoD1 demonstration in routinely processed tissue sections using wet heat pretreatment (pressure cooking) for antigen retrieval
  • Epstein-Barr virus in Hodgkin's disease: Frequency of a 30-bp deletion in the latent membrane protein 1 (LMP-1) oncogene in South African patients
  • Improved prognosis of Epstein-Barr virus associated childhood Hodgkin's lymphoma: Study of 47 South African cases
  • Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study.
  • Rheumatic Heart Disease: The time has come.
  • Long-awaited update on estimates of acute rheumatic fever in Africa
  • The incidence of sore throat and group A streptococcal pharyngitis in children at high risk of developing acute rheumatic fever: A systematic review and meta-analysis
  • No evidence for an association between the mitochondrial variant T16189C and dilated cardiomyopathy: A systematic review and meta-analysis
  • Epstein-Barr virus in Hodgkin's disease: Frequency of a 30-bp deletion in the latent membrane protein 1 (LMP-1) oncogene in South African patients
  • Investigation for a 30bp deletion in the EBV LMP oncogene in South African Hodgkin's disease
  • Prevalence of group A Streptococcal infection in Africa to inform GAS vaccines for rheumatic heart disease: A Systematic review and Meta-analysis.
  • Acute rheumatic fever surveillance in South Africa: An evaluation tool based on the CDC guidelines for evaluating public health surveillance systems
  • Factors associated with tuberculosis diagnosis and treatment delays in Middle East and North Africa: a systematic review.
  • A Patient-Specific CFD Pipeline Using Doppler Echocardiography for Application in Coarctation of the Aorta in Limited Resource Clinical Context.
  • The effectiveness of peer and community health worker-led self-management support programs for improving diabetes health-related outcomes in adults in low-and-middle-income countries: A systematic review.
  • Improved prognosis of Epstein-Barr virus associated childhood Hodgkin's lymphoma: study of 47 South African cases
  • Genetic contribution to rheumatic fever: A systematic review and meta-analysis of twin studies
  • Paediatric rhabdomyosarcoma: MyoD1 demonstration in routinely processed tissue sections using wet heat pretreatment (pressure cooking) for antigen retrieval
  • Prevalence of rheumatic heart disease in 4720 asymptomatic scholars from South Africa and Ethiopia
  • The Importance of Awareness and Education in Prevention and Control of RHD
  • Regional patterns and the association between obesity and hypertension in Africa: 30,044 participants from the H3Africa CHAIR study across 13 countries.
  • The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol.
  • Regional Patterns and Association Between Obesity and Hypertension in Africa Evidence From the H3Africa CHAIR Study
  • Prevalence of group A β-hemolytic streptococcal throat carriage and prospective pilot surveillance of streptococcal sore throat in Ugandan school children
  • The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis
  • Long-awaited update on estimates of acute rheumatic fever in Africa.
  • Prevalence and distribution of HPV infection and subtypes in oral squamous cell carcinoma in Africa: a systematic review protocol
  • Utility of Human Immune Responses to GAS Antigens as a Diagnostic Indicator for ARF: A Systematic Review
  • Understanding the local and international stakeholders in rheumatic heart disease field in Tanzania and Uganda: A systematic stakeholder mapping
  • Data independent acquisition mass spectrometry in severe Rheumatic Heart Disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
  • Risk of immune reconstitution inflammatory syndrome with integrase inhibitors versus other classes of antiretrovirals
  • How do we measure the implementation of the World Health Assembly resolution on rheumatic fever and rheumatic heart disease in African countries? Rationale and design of an evidence-based scorecard
  • Primary prevention of acute rheumatic fever and rheumatic heart disease
  • International Travel-Related Control Measures to contain The Covid-19 Pandemic: An update to a Cochrane Rapid Review
  • Long-awaited update on estimates of acute rheumatic fever in Africa Comment
  • Long-awaited update on estimates of acute rheumatic fever in Africa.
  • A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis
  • International air travel-related control measures to contain the Covid-19 pandemic: A companion review to a Cochrane rapid review
  • Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections
  • Consumption of Aloe to improve health outcomes in adults with irritable bowel syndrome: A systematic review and meta-analysis
  • Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†
  • American Heart Association's Children's Strategically Focused Research Network Experience
  • The severe presentation and poor outcomes of rheumatic heart disease in Namibia: Lessons from the REMEDY study
  • ‘Listen to my heart’: Qualitative researchers and people living with rheumatic heart disease collaborate to direct future RHD research
  • Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
  • Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol
  • Diagnostic test accuracy of artificial intelligence in screening for referable diabetic retinopathy in real-world settings: A systematic review and meta-analysis
  • Serum Immune Responses to Group A Streptococcal Antigens following Pharyngeal Acquisitions among Children in Cape Town, South Africa
  • The prevalence of pulmonary hypertension in post-tuberculosis and active tuberculosis populations: a systematic review and meta-analysis
  • Evaluating the utility of the Allplex STI essential assay to determine the occurrence of urogenital sexually transmitted infections among symptomatic and asymptomatic patients in Cape Town, South Africa
  • Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report
  • Presence of Group A streptococcus (GAS) frequently assayed virulence genes in invasive disease: a systematic review and meta-analysis
  • A survey of antibiotic resistance patterns among Group A Streptococcus isolated from invasive and non-invasive infections in Cape Town, South Africa.
  • Diagnostic Accuracy of Computer-Aided Detection During Active Case Finding for Pulmonary Tuberculosis in Africa: A Systematic Review and Meta-analysis
  • Mobile Phone Text Message Reminders to Improve Vaccination Uptake: A Systematic Review and Meta-Analysis

Mark Engel's public data