Mark Engel

Publications

• Is the introduction of violence and injury observatories associated with a reduction in violence-related injury in adult populations? A systematic review and meta-analysis
• Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: A systematic review and meta-analysis
• Seven key actions to eradicate rheumatic heart disease in Africa: the Addis Ababa communique
• Data Resource Profile: Cardiovascular H3Africa Innovation Resource (CHAIR)
• Regional Patterns and Association Between Obesity and Hypertension in Africa Evidence From the H3Africa CHAIR Study
• Reducing the Burden of Rheumatic Heart Disease: Prevalence of Group a Streptococcus emm Clusters in Africa Suggests Adequate Coverage by 30-Valent Vaccine
• Prevalence of group A Streptococcal infection in Africa to inform GAS vaccines for rheumatic heart disease: A systematic review and meta -analysis
• Correction: Rationale and design of the African group A streptococcal infection registry: The AFROStrep study (BMJ Open (2016) 6, (e010248))
• Integrating the prevention and control of rheumatic heart disease into country health systems: A systematic review protocol
• The effectiveness of peer and community health worker-led self-management support programs for improving diabetes health-related outcomes in adults in low- and-middle-income countries: A systematic review
• Erratum for Barth et al., "Molecular Epidemiology of Noninvasive and Invasive Group A Streptococcal Infections in Cape Town"
• Parents of children with disabilities: A systematic review of parenting interventions and self-efficacy
• Rationale and design of the African group A streptococcal infection registry: the AFROStrep study
• Factors associated with long-term mortality after Fontan procedures: a systematic review
• Invasive and non-invasive group A β-haemolytic streptococcal infections in patients attending public sector facilities in South Africa: 2003–2015
• Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease
• The Health Systems Barriers and Facilitators for RHD Prevalence: An Epidemiological Meta-Analysis From Uganda and Tanzania
• The Cape Town Clinical Decision Rule for Streptococcal Pharyngitis in Children
• Predicting long-term mortality after Fontan procedures: A risk score based on 6707 patients from 28 studies
• Prevalence and risk factors of latent tuberculosis infection in Africa: a systematic review and meta-analysis protocol
• Asymptomatic rheumatic heart disease in South African schoolchildren: Implications for addressing chronic health conditions through a school health service
• Participation in research improves overall patient management: insights from the Global Rheumatic Heart Disease registry (REMEDY)
• Evaluation of a focussed protocol for hand-held echocardiography and computer-assisted auscultation in detecting latent rheumatic heart disease in scholars
• Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis
• Clinical Outcomes in 3343 Children and Adults with Rheumatic Heart Disease from 14 Low-and Middle-Income Countries: Two-Year Follow-Up of the Global Rheumatic Heart Disease Registry (the REMEDY Study)
• Seven key actions to eradicate rheumatic heart disease in Africa: The Addis Ababa communiqu
• Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations
• Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever
• Task sharing to improve the prevention, diagnosis and management of rheumatic heart disease: A systematic review protocol
• Rationale and design of the violence, injury and trauma observatory (VITO): The Cape Town VITO pilot studies protocol
• Prevalence of rheumatic heart disease in Zambian school children
• Standard echocardiography versus handheld echocardiography for the detection of subclinical rheumatic heart disease: Protocol for a systematic review
• Effectiveness of control measures to prevent occupational tuberculosis infection in health care workers: A systematic review
• Task Sharing in the Diagnosis, Prevention, and Management of Rheumatic Heart Disease: A Systematic Review
• Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa: A systematic review protocol
• Prevalence of rheumatic heart disease among school children in Ethiopia: A multisite echocardiography-based screening
• Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: A systematic review and meta-analysis
• A Comprehensive Needs Assessment Tool for Planning RHD Control Programs in Limited Resource Settings
• Is computer-assisted instruction more effective than other educational methods in achieving ECG competence among medical students and residents? Protocol for a systematic review and meta-analysis
• Digoxin and clinical outcomes in the Global Rheumatic Heart Disease Registry
• Genetic variants in rheumatic fever and rheumatic heart disease
• Systematic review and meta-analysis of the prevalence of Strep A emm clusters in Africa to inform vaccine development
• Does genetics matter for disease-related stigma? The impact of genetic attribution on stigma associated with rheumatic heart disease in the Western Cape, South Africa
• Systematic Review and Meta-analysis of the Prevalence of Group A Streptococcal emm Clusters in Africa To Inform Vaccine Development
• Molecular Epidemiology of Noninvasive and Invasive Group A Streptococcal Infections in Cape Town
• Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis
• Rapid review of Global Strep A emm types
• Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals
• An appraisal of laboratory models of androgenetic alopecia: A systematic review
• Outcomes and complications of peripartum cardiomyopathy: protocol for a systematic review and meta-analysis
• Rheumatic Fever: Neglected Again
• Primary Prevention of Acute Rheumatic Fever and Rheumatic Heart Disease with Penicillin in South African Children with Pharyngitis: A Cost-Effectiveness Analysis
• The Rheumatic Heart Disease Global Registry (REMEDY) study: preliminary report
• Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review
• Primary prevention of rheumatic fever in children: Key factors to consider Respone
• Irlam et al. respond.
• Erratum: (BMJ Open (2015) 5)
• Incidence, prevalence and outcome of rheumatic heart disease in South Africa: A systematic review of contemporary studies
• Tuberculosis surveillance in Cape Town, South Africa: an evaluation
• Abnormal glucose metabolism in non-diabetic patients presenting with an acute stroke: prospective study and systematic review
• Effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town: no evidence for an association
• Prevalence of group A streptococcal disease in North and Sub-Saharan Africa: a systematic review protocol
• Group A streptococcal emm type prevalence among symptomatic children in Cape Town and potential vaccine coverage
• Clinical and epidemiological aspects of streptococcus pyogenes pharyngitis and carriage in Africa.
• Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials
• A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis
• Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review
• The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis
• Is the introduction of violence and injury observatories associated with a reduction of violence in adult populations? Rationale and protocol for a systematic review
• Genetic susceptibility to acute rheumatic Fever: a systematic review and meta-analysis of twin studies
• Rheumatic heart disease in Africa: the Mosi-o-Tunya call to action
• Rationale and design of a Global Rheumatic Heart Disease Registry: the REMEDY study
• Mobile phone text messaging for improving the uptake of vaccinations: a systematic review protocol
• An open-access, mobile compatible, electronic patient register for rheumatic heart disease ('eRegister') based on the World Heart Federation's framework for patient registers
• The prevalence of type 2 diabetes among older people in Africa: a systematic review
• N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review protocol
• Rheumatic fever and rheumatic heart disease: Where are we now in South Africa?
• Research capacity. Enabling the genomic revolution in Africa
• Primary prevention of acute rheumatic fever and rheumatic heart disease with penicillin in South African children with pharyngitis: a cost-effectiveness analysis
• Prevalence of rheumatic heart disease in 4720 asymptomatic scholars from South Africa and Ethiopia
• The prevalence of type 2 diabetes mellitus among older people in Africa: a systematic review study protocol
• Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review.
• Rheumatic fever: Neglected again
• Re: Primary prevention of rheumatic fever in children: Key factors to consider
• Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study
• Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: The Global Rheumatic Heart Disease Registry (the REMEDY study)
• Letter to the editor
• The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: A systematic review protocol
• Effectiveness of community-based peer-led diabetes self-management programmes (COMP-DSMP) for improving clinical outcomes and quality of life of adults with diabetes in primary care settings in low and middle-income countries (LMIC): A systematic review and meta-analysis
• The natural history of latent rheumatic heart disease in a 5 year follow-up study: A prospective observational study
• The burden of antenatal heart disease in South Africa: A systematic review
• Mycobacterium w immunotherapy for treating pulmonary tuberculosis - A systematic review
• A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development
• The importance of awareness and education in prevention and control of RHD
• The second rheumatic heart disease forum report
• Health education interventions to raise awareness of rheumatic fever: a systematic review protocol.
• Incidence, prevalence and outcomes of rheumatic heart disease in South Africa: A systematic review protocol
• Rheumatic Fever: Neglected Again
• The Rheumatic Heart Disease Global Registry (REMEDY) study: preliminary report
• Primary prevention of rheumatic fever in children: Key factors to consider Respone
• Mobile phone text messaging for improving the uptake of vaccinations: a systematic review protocol
• Mycobacterium w immunotherapy for treating pulmonary tuberculosis - a systematic review
• Investigation for a 30bp deletion in the EBV LMP oncogene in South African Hodgkin's disease
• No evidence for an association between the mitochondrial variant T16189C and dilated cardiomyopathy: A systematic review and meta-analysis
• Acute rheumatic fever surveillance in South Africa: An evaluation tool based on the CDC guidelines for evaluating public health surveillance systems
• Genetic contribution to rheumatic fever: A systematic review and meta-analysis of twin studies
• Prevalence of Group A -hemolytic Streptococcal Throat Carriage and Prospective Pilot Surveillance of Streptococcal Sore Throat in Ugandan School Children
• Regional patterns and the association between obesity and hypertension in Africa: 30,044 participants from the H3Africa CHAIR study across 13 countries.
• Is computer-assisted instruction more effective than other educational methods in achieving ECG competence amongst medical students and residents? A systematic review and meta-analysis
• RHD Forum Meeting Report Writing Committee. The Second Rheumatic Heart Disease Forum Report.
• Corticosteroids for tuberculous pleurisy
• Conducting a meta-ethnography of qualitative literature: lessons learnt
• Patient adherence to tuberculosis treatment: a systematic review of qualitative research
• The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
• Rheumatic Heart Disease: The time has come.
• Detection of EBV in 48 cases of South African childhood Hodgkin's disease
• Paediatric rhabdomyosarcoma: MyoD1 demonstration in routinely processed tissue sections using wet heat pretreatment (pressure cooking) for antigen retrieval
• Epstein-Barr virus in Hodgkin's disease: Frequency of a 30-bp deletion in the latent membrane protein 1 (LMP-1) oncogene in South African patients
• Improved prognosis of Epstein-Barr virus associated childhood Hodgkin's lymphoma: Study of 47 South African cases
• Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study.
• Rheumatic Heart Disease: The time has come.
• Long-awaited update on estimates of acute rheumatic fever in Africa
• The incidence of sore throat and group A streptococcal pharyngitis in children at high risk of developing acute rheumatic fever: A systematic review and meta-analysis
• No evidence for an association between the mitochondrial variant T16189C and dilated cardiomyopathy: A systematic review and meta-analysis
• Epstein-Barr virus in Hodgkin's disease: Frequency of a 30-bp deletion in the latent membrane protein 1 (LMP-1) oncogene in South African patients
• Investigation for a 30bp deletion in the EBV LMP oncogene in South African Hodgkin's disease
• Prevalence of group A Streptococcal infection in Africa to inform GAS vaccines for rheumatic heart disease: A Systematic review and Meta-analysis.
• Acute rheumatic fever surveillance in South Africa: An evaluation tool based on the CDC guidelines for evaluating public health surveillance systems
• Factors associated with tuberculosis diagnosis and treatment delays in Middle East and North Africa: a systematic review.
• A Patient-Specific CFD Pipeline Using Doppler Echocardiography for Application in Coarctation of the Aorta in Limited Resource Clinical Context.
• The effectiveness of peer and community health worker-led self-management support programs for improving diabetes health-related outcomes in adults in low-and-middle-income countries: A systematic review.
• Improved prognosis of Epstein-Barr virus associated childhood Hodgkin's lymphoma: study of 47 South African cases
• Genetic contribution to rheumatic fever: A systematic review and meta-analysis of twin studies
• Paediatric rhabdomyosarcoma: MyoD1 demonstration in routinely processed tissue sections using wet heat pretreatment (pressure cooking) for antigen retrieval
• Prevalence of rheumatic heart disease in 4720 asymptomatic scholars from South Africa and Ethiopia
• The Importance of Awareness and Education in Prevention and Control of RHD
• Regional patterns and the association between obesity and hypertension in Africa: 30,044 participants from the H3Africa CHAIR study across 13 countries.
• The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol.
• Regional Patterns and Association Between Obesity and Hypertension in Africa Evidence From the H3Africa CHAIR Study
• Prevalence of group A β-hemolytic streptococcal throat carriage and prospective pilot surveillance of streptococcal sore throat in Ugandan school children
• The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis
• Long-awaited update on estimates of acute rheumatic fever in Africa.
• Prevalence and distribution of HPV infection and subtypes in oral squamous cell carcinoma in Africa: a systematic review protocol
• Utility of Human Immune Responses to GAS Antigens as a Diagnostic Indicator for ARF: A Systematic Review
• Understanding the local and international stakeholders in rheumatic heart disease field in Tanzania and Uganda: A systematic stakeholder mapping
• Data independent acquisition mass spectrometry in severe Rheumatic Heart Disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
• Risk of immune reconstitution inflammatory syndrome with integrase inhibitors versus other classes of antiretrovirals
• How do we measure the implementation of the World Health Assembly resolution on rheumatic fever and rheumatic heart disease in African countries? Rationale and design of an evidence-based scorecard
• Primary prevention of acute rheumatic fever and rheumatic heart disease
• International Travel-Related Control Measures to contain The Covid-19 Pandemic: An update to a Cochrane Rapid Review
• Long-awaited update on estimates of acute rheumatic fever in Africa Comment
• Long-awaited update on estimates of acute rheumatic fever in Africa.
• A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis
• International air travel-related control measures to contain the Covid-19 pandemic: A companion review to a Cochrane rapid review
• Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections
• Consumption of Aloe to improve health outcomes in adults with irritable bowel syndrome: A systematic review and meta-analysis
• Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†
• American Heart Association's Children's Strategically Focused Research Network Experience
• The severe presentation and poor outcomes of rheumatic heart disease in Namibia: Lessons from the REMEDY study
• ‘Listen to my heart’: Qualitative researchers and people living with rheumatic heart disease collaborate to direct future RHD research
• Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
• Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol
• Diagnostic test accuracy of artificial intelligence in screening for referable diabetic retinopathy in real-world settings: A systematic review and meta-analysis
• Serum Immune Responses to Group A Streptococcal Antigens following Pharyngeal Acquisitions among Children in Cape Town, South Africa
• The prevalence of pulmonary hypertension in post-tuberculosis and active tuberculosis populations: a systematic review and meta-analysis
• Evaluating the utility of the Allplex STI essential assay to determine the occurrence of urogenital sexually transmitted infections among symptomatic and asymptomatic patients in Cape Town, South Africa
• Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report
• Presence of Group A streptococcus (GAS) frequently assayed virulence genes in invasive disease: a systematic review and meta-analysis
• A survey of antibiotic resistance patterns among Group A Streptococcus isolated from invasive and non-invasive infections in Cape Town, South Africa.
• Diagnostic Accuracy of Computer-Aided Detection During Active Case Finding for Pulmonary Tuberculosis in Africa: A Systematic Review and Meta-analysis
• Mobile Phone Text Message Reminders to Improve Vaccination Uptake: A Systematic Review and Meta-Analysis
• Presence of Group A streptococcus frequently assayed virulence genes in invasive disease: a systematic review and meta-analysis
• Prevalence of sudden unexpected death of infants and its subcategories in low- or middle-income countries: a systematic review protocol
• Assessing the evidence for antibiotic management of laboratory-confirmed Streptococcus A skin infections to prevent acute rheumatic fever and rheumatic heart disease: A systematic review